Where is it fashionable/convenient to make site layouts nowadays?

Question

Layouts and prototypes

There is a drawing with a pen, you need to make a beautiful even layout, and it is desirable that it would be clickable.
What options are now most commonly used for this purpose?

Answer 1

moqups.com

Answer 2

Axure is considered the best.

Answer 3

gomockingbird.com

Answer 4

As mentioned above, Axure RP is the most famous.
If you just need to roll out a layout quickly, I use LayoutIt!

Answer 5

Fireworks is good, especially if you plan to smoothly design later. Well, just a fairy tale for layout and subsequent design.
There are libraries of twitter bootstrap elements and not only.

Answer 6

I use Balsamiq Mockups