How to draw application design for PC?

Question

User interface

There is a task: to create a design for a separate application module for PC (the central part, additional information will be displayed on the sides). In this case, it is necessary to show adaptability to different resolutions.
1. How to make adaptive: rubber/breakpoints?
2. If we mean using the application on win10, then as elements (checkboxes, radio buttons, text fields) it is necessary to take elements from the fluent design ui kit?
3. Are there any fundamental differences from web layout design?

Answer 1

In Qt Designer, you can draw.