Will programs work after disk cloning if you change the letter of the new disk to the letter of the old one?

Question

Iron

There is a dying hard drive and another, new one. At the moment they are both connected, so they have different letters. If you make a clone of the old one from the new disk, then remove the old one and change the letter of the new one to the letter of the old one, will the programs work?
UPD. I forgot to say about the OS, Win7.
UPD2. The system itself is on an SSD, it is the programs that need to be transferred, and not the entire system.

Answer 1

At least clone disks, at least stupidly copy everything from the old to the new one, at least make a logical disk on the new one and copy everything there from the old one, then change the letters, turn off, turn off the old one and turn it on - they should work.
Try it, you have nothing to lose.

Answer 2

Make a copy of the old disk to a new one, for example, using Clonezilla , and you will be happy.

Answer 3

You can take an image of the affected disk to an external drive, cut off the required amount of space from the disk where you want to transfer it, and deploy the image to it as a separate partition. We turn off the old disk, assign its letter to the new partition.
All this can be done with free software like AOMEI Backupper \ Partition Assistant.
Naturally, before ANY disk operations, a conscious person has a fresh backup of all the disks on which they are performed.