Optimal size for a block in a layout?

Question

css

I usually make a horizontal layout. indented, fixed blocks became interesting. ( https://www.twitch.tv/directory/game/Dark%20Souls%20III , for example, or - a couple of pictures for the entire width of the monitor, without padding)
Question: What size is needed for the layout? (Optimal, avoiding padding)

Answer 1

Yourself, what do you think? We look at statistics and draw conclusions.