Is registry defragmentation effective?

Question

System administration

Too lazy to climb with handles, so I set up TuneUp Utilities 2018 for myself to clean the computer.
Inside there is an option "Registry defragmentation".
Usually the program offers to execute it either after the first launch, or if a lot of software has been uninstalled. The rest of the time he says that everything is OK with the registry.
For the operation, you need to restart the computer and it goes through until Windows starts.
Does this procedure have any noticeable effect on the system?

Answer 1

No.
There were certain problems with registry defragmentation in older systems up to and including WinXP, especially on the FAT32 file system, in modern systems everything is in order with this - the system performs some optimization, but nothing more can be done.
Therefore, defragmenting the registry with third-party utilities is at least useless, and often harmful.
The same can be said about all software like TuneUp Utilities and the like.

Answer 2

Generally not effective. This is the same nonsense as antivirus for iOS

Answer 3

Some - probably renders. If, for example, I installed twenty programs, then randomly demolished ten of them, and these are programs of the AutoCAD class. Or if it has not been held for several years. Theoretically, a registry that goes in continuous blocks loads faster. In practice, it is difficult to find confirmation of this (at least starting from Win7 I don’t notice anything. On WinXP it was noticeable, sometimes even significantly)