Is it possible to make a color change animation from two identical 2D drawings?

Question

Unity

My goal is to draw graphics in my game by hand and scan, etc., but there is a problem, I will need to create animation like a regular house, for example, it will change color to another, but in such a way that it is filled with water, like water in you pour a glass, or as if from one point the whole object is slowly and smoothly filled. The question is, is it possible to create two absolutely identical houses, one of one color and the other of another. And with the help of the program to create this effect, animation, or you will need to draw a lot of the same thing to do so.