How to set permissions for folders when accessing a site running under windows?

Question

IIS

They asked me to look at one site, but the eccentric keeps it at home on a computer under windows. As a result, I can not set the rights to either folders or files - everywhere it costs 0000. As a result, the scripts are buggy. Question: how to set the rights to folders and can it affect the operation of the site? Everything works for him (locally).