What to include from available? G sync in driver or amd freesync premium in monitor?

Question

Acer

There is an Acer Nitro XV282K KV monitor
There is HDMI 2.1 (which by the way also supports VRR)
There is a microsoft flight simulator 2020 game
I want a smooth picture without gaps. But what's the point of including v-sync in 4 places? Will it work then if you turn it on in 4 places at once?
Vsync in the game I think it makes no sense to include. But it's not clear in the nvidia control panel either? whether to enable if amd freesync premium is enabled on the monitor. And how does VRR work from HDMI 2.1? does it interfere with other synchronizers?
Because I have a video card from nvidia, so far I'm inclined to cut down Vsync and amd freesync premium. Leave G sync in nvidia control panel.
As a result, while the situation is this:
Vsync -
amd freesync premium -
G-sync +
HDMI 2.1 +
But if someone is more expert in this, then I would like some advice.