What protocols are more profitable and more reliable to use for requests from the client to the Asp.Net Web Api server?

Question

ASP.NET

Good day. Faced another problem with the implementation of the server on an external hosting Asp.Net. Namely, "which protocol is more profitable and more reliable to use for server requests?" and "how will this protocol behave asynchronously?"
The server is designed to work with the game in Unity i.e. requests to write, change and delete values ​​in the database.

Answer 1

SignalR + MessagePack Hub Protocol