Is there a difference in the operation of the RAM with 1x16gb or 2x8gb?

Question

RAM

Hello. Actually interesting.
ddr4 memory.
Is there a difference in performance or in other parameters
Between 1x16gb (one RAM for 16GB)
and
2x8gb (2 RAMs for 8GB each)
Or the performance in such scenarios will be the same or almost and there is no point in the experiment))