Chrome Browser Configuration: Is Automation Possible?

Question

Google Chrome

We use Google Chrome as a corporate browser.
Some external service needs to add certain explicit permissions.
These are the following:
Settings > Advanced > Privacy and security > Content settings > Flash
There you need to add some allowed domains.
There are about 300 jobs in the organization, there is some movement of employees and turnover.
And this setting is stored in %AppData% of the user profile, and not for the entire host.
Is there any way to avoid manually editing this setting for each user at each workstation?