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Ilya Kovalevsky2013-02-02 15:12:05
Programming
Ilya Kovalevsky, 2013-02-02 15:12:05

Biology consultation?

Hey!
I need to build an application that from one cell, by dividing, grows millions of independent cells. The fact is that I do not understand how it all happens (transfer of hereditary information, mutations, etc).
The goal is to programmatically model a biological organism and perform various manipulations on it (its cells), so to speak.
Can anyone help me understand biology? Or advise some tutorials, articles, guides?
Thank you.

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5 answer(s)
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NightBlade, 2013-02-02
@namespace

Documentary series about the cell, in which you can learn about their division, transfer of hereditary information and mutation :
vk.com/video-18951849_164693217

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oldbay, 2013-02-02
@oldbay

There are too many nuances in the question:

to simulate a biological organism programmatically and conduct over it

So is it a multicellular organism?
I need to build an application that from one cell, by dividing, grows millions of independent cells

but then the cells of this organism cannot be independent (they are differentiated into tissues and organs) and division is strictly regulated by the humoral system of the organism - otherwise it is a cancerous tumor.

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kablag, 2013-02-11
@kablag

What manipulations do you want to carry out specifically? I think you will not be able to embrace all the processes in the cell. You need to stop at a certain level of abstraction.
Here is an example of development from unicellular to multicellular: www.evolbiol.ru/doklad_seminar_20.htm

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Arthur K., 2016-03-11
@amark

do not forget to add random mutations to the genes)

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Mikhail Potanin, 2016-11-17
@potan

The task is not very clear. Are they independent cells or a multicellular organism? At what level should modeling be carried out?
In full, such a project will draw on a doctoral degree.
If individual cells are modeled, then the most important thing to consider is that there is a discrete superset of traits that is inherited, and mutations affect the degree of manifestation of a particular trait (for example, the ability to eat not glucose, but some kind of malate). It is interesting, but very difficult, to model regulation - when a sign is the degree of dependence of the manifestation of other signs on the external environment. A model will also be needed that evaluates the success of this cell depending on the set of trait genes (should it take into account the influence of other cells? Is helping sister cells a success?).
If these cells can reproduce sexually, then for each cell it is necessary to model two sets of genes responsible for each trait, and somehow interacting with each other (recessive-dominant or something more complex). The daughter cell must receive one trait from each pair from each parent (this model can also be complex - for example, "adjacent traits" whose genes are located on the same chromosome are more likely to pass from one parent together).
Most likely, multicellular organisms should be approached from a different angle. Alexander Markov has a simulation program where a script is written for a cell that decides when to divide, when to grow, when to send signals to neighboring cells, when to stick to them, when to separate. The cells themselves were modeled as elastic balls.

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