Which is better: Wine or software based on it?

Question

linux

Hello. Subject. And maybe some new ones have appeared, I only know playonlinux and crossover

Answer 1

depending on the software you are virtualizing.
some of it works better in some, some in others,
some don't care.

Answer 2

What the program will work on. In wine, it's all very individual.

Answer 3

better for what?
Steam Proton has almost no alternative if normal hardware with Vulkan support.