What is better to use for Python 3 when creating GUI under Windows?

Question

Python

Good day,
The task was to create a simple Python program for Windows XP/Vista/7/8/10.
It should be a simple window with a couple of buttons and colored fonts that will look as uniform as possible with the system and run from a flash drive with one exe file
. I came across 2 options:
PyQT - but as far as I understand it has a specific QT view of the Tkinter interface -
which is included in the basic package and looks more uniform in the system

Answer 1

Qt has no specific interface. Change as you wish. So far - this is the best option for a desktop application

Answer 2

On the contrary, Qt Widgets (not QML) has a system L&F, but Tkinter does not, in addition to these libraries, there are also wxWidgets and GTK, choose, but for Windows it is better to write not in Python, but in C #, Delphi, PureBasic, PowerBASIC.