Regular expression. Anything but 1, a,?

Question

JavaScript

The string can start with any character except "1, a and ?"
The line start character is understandable "^". But how to put a negative? At what and groups of characters az and for a certain set of characters "hello".
I'll give you an example.
I want to say a line that does not start with 1 and then something follows, for example the word "hello"
1hello
6hello
*hello
7hello
dhello
In general, I need exactly negation and not enumeration of other options.
I'm asking for general development and not for assignment.

Answer 1

/^[^1a?].*\b/