How to remove buttons?

Question

Python

Hello!
How to remove these buttons after being clicked on.
Here is the button code

markup = types.ReplyKeyboardMarkup(resize_keyboard=True)
    item1 = types.KeyboardButton("Да")
    item2 = types.KeyboardButton("Нет")
    markup.add(item1, item2)
    bot.send_message(message.from_user.id,' text ', reply_markup=markup)

Thanks in advance. This is a telegram bot.