How to create a proxy bound to an interface and deny other traffic?

Question

proxy

Windows 7.
The system has two network cards. Both provide access to the Internet. It is necessary to create a proxy server, binding it to one of the network, while blocking the ability to go traffic (both outgoing and incoming) through this network bypassing the proxy .
Question: what is the easiest and most reliable way to do this?
ps The network receives settings via DHCP, so it is highly undesirable to bind a proxy server to an IP address. It would be desirable to bind it to GUID'u network.