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Exchange server 2016 on a single server, is it possible and reasonable?
PDC understandably, lives on a separate piece of iron.
~ 500 mailboxes, ~3k emails per day
HP ProLiant DL180 Gen9 with one Xeon E5-2623, 32GB RAM, 12 x SATA - more than enough?
High availability and site resilience - is not a mandatory requirement, "death" of mail for a day or two is not critical. It is clear that a server without redundancy is not good, but in general does such a practice have the right to life?
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Quite. Just make backups, especially since exchange allows you to do this without stopping the service.
The number of letters is nothing at all, the question is in the size of storage and its growth.
If users regularly clean letters, and the total volume allows you to make backups, and in which case, recovery will not take much time - no problem.
For example, if the storage is 1 TB, then in principle you can make a backup even daily. If 10 TB, then it is already expensive both in time and in place. If more, it is not clear how long it will be copied at all.
Otherwise - with the requirement that a day or two is not critical - 1 server + backups is more than enough
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