Do I need to stick to a specific divisor or powers of two in sprite size?

Question

Design

When drawing sprites in pixel art for a 2D game, do I need to stick to certain divisors to resolve sprites, or should it always be a multiple of two?

Answer 1

Then all the same, in a high degree of probability you will glue it into an atlas, so it does not matter.
But the atlas itself is already adjusted to the minimum power of two.

Answer 2

Are you making a game for some prehistoric console that doesn't support numbers greater than 2^3? Or maybe the game engine can only work with squares? If there are no such restrictions, then there is no reason to adhere to something there. Draw in a way that is beautiful and comfortable.