Are there ways to determine if an object is touching another, yet allowing one object to pass through the other?

Question

Unity

I am making a 2D game, the meaning of which is to destroy falling objects by pressing the right keys. There was a problem with prescribing a script to prohibit clicking while the object is in the desired zone. How can I install a kind of collider on this zone to find out if the object and the zone are in contact. Is it possible? Unfortunately I have tried all possible other ways but for some different reasons it is not possible the

purple stripe is the same zone, objects are falling from above
please help if possible

Answer 1

OnTriggerEnter2D or what?